Neurogastroenterol Motil. 2024 Apr 12:e14797. doi: 10.1111/nmo.14797. Online ahead of print.

Nessmah Sultan ^1 2, Mandy Foyster ¹, Matilda Tonkovic ¹, Danielle Noon ^1 3, Helen Burton-Murray ^4 5, Jessica R Biesiekierski ^1 2, Caroline J Tuck ^1 3

Author information

¹Department of Food, Nutrition and Dietetics, La Trobe University, Bundoora, Victoria, Australia.

²Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, Victoria, Australia.

³Department of Nursing and Allied Health, Swinburne University, Hawthorn, Victoria, Australia.

⁴Harvard Medical School, Boston, Massachusetts, USA.

⁵Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Abstract

Introduction: Orthorexia, a harmful obsession with eating healthily, may develop from illnesses characterized by dietary restriction, including irritable bowel syndrome (IBS) and eating disorders (ED). Evidence of disordered eating in IBS exists, but orthorexia has not been assessed. This cross-sectional study in adults (≥18 years) assessed presence and characteristics of disordered eating and orthorexia in IBS, compared to control subjects (CS) and ED.

Methods: IBS participants met Rome IV, and ED participants met DSM-5 criteria. Disordered eating was assessed using "sick, control, one-stone, fat, food" (SCOFF, ≥2 indicating disordered eating), and orthorexia by the eating habits questionnaire (EHQ). Secondary measures included stress (PSS); anxiety (HADS-A); food-related quality of life (Fr-QoL), and dietary intake (CNAQ).

Key results: In 202 IBS (192 female), 34 ED (34 female), and 109 CS (90 female), more IBS (33%) and ED (47%) scored SCOFF≥2 compared to CS (16%, p < 0.001, chi-square). IBS and ED had higher orthorexia symptom severity compared to CS (EHQ IBS 82.9 ± 18.1, ED 90.1 ± 19.6, and CS 73.5 ± 16.9, p < 0.001, one-way ANOVA). IBS and ED did not differ for SCOFF or EHQ (p > 0.05). Those with IBS and disordered eating had higher orthorexia symptom severity (EHQ 78.2 ± 16.6 vs. 92.4 ± 17.5, p < 0.001, independent t-test), worse symptoms (IBS-SSS 211.0 ± 78.4 vs. 244.4 ± 62.5, p = 0.008, Mann-Whitney U test), higher stress (p < 0.001, independent t-test), higher anxiety (p = 0.002, independent t-test), and worse FR-QoL (p < 0.001, independent t-test).

Conclusions and inferences: Disordered eating and orthorexia symptoms occur frequently in IBS, particularly in those with worse gastrointestinal symptoms, higher stress, and anxiety. Clinicians could consider these characteristics when prescribing dietary therapies.