Weaver KN¹, Kochar B^1,2, Hansen JJ^1,2,3, Isaacs KL^1,2,3, Jain A^1,2,3, Sheikh SZ^1,2,3, Fichera A^2,4, Chaumont N^2,4, Sadiq T^2,4, Koruda M^2,4, Long MD^1,2,3, Herfarth HH^1,2,3, Barnes EL^1,2,3. Crohns Colitis 360. 2019 Oct;1(3):otz029. doi: 10.1093/crocol/otz029. Epub 2019 Sep 26.

Author information

1 Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC.

2 Multidisciplinary Center for Inflammatory Bowel Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC.

3 Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC.

4 Division of Gastrointestinal Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Abstract

BACKGROUND: Risk factors for the development of chronic antibiotic dependent pouchitis (CADP) are not well understood.

METHODS: Using multivariable logistic regression, we compared clinical factors between 194 patients with acute antibiotic responsive pouchitis or CADP.

RESULTS: Individuals with CADP were significantly older (40.9 vs 30.8 years, P < 0.001) and demonstrated a longer diseaseduration before IPAA (10.3 vs 7.0 years, P = 0.004). Age ≥55 years at the time of IPAA was significantly associated with CADP (adjusted odds ratio = 4.35, 95% confidence interval = 1.01-18.7).

CONCLUSIONS: Although older age should not represent a barrier to IPAA, further studies evaluating etiologies of this association are warranted.