Semin Neurol. 2023 Aug;43(4):572-582. doi: 10.1055/s-0043-1771467.Epub 2023 Aug 10.

Grace E Hey ¹, Vinata Vedam-Mai ¹, Matthew Beke ^1 2, Manuel Amaris ³, Adolfo Ramirez-Zamora ¹

Author information

¹Department of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida.

²Department of Food Science and Human Nutrition, University of Florida, Gainesville, Florida.

³Department of Gastroenterology, University of Florida, Gainesville, Florida.

Abstract

Inflammatory Bowel Disease (IBD) is a complex, chronic inflammatory condition affecting the gastrointestinal tract. IBD has been associated with a variety of neurologic manifestations including peripheral nerve involvement, increased risk of thrombotic, demyelinating and events. Furthermore, an evolving association between IBD and neurodegenerative disorders has been recognized, and early data suggests an increased risk of these disorders in patients diagnosed with IBD. The relationship between intestinal inflammatory disease and neuroinflammation is complex, but the bidirectional interaction between the brain-gut-microbiome axis is likely to play an important role in the pathogenesis of these disorders. Identification of common mechanisms and pathways will be key to developing potential therapies. In this review, we discuss the evolving interface between IBD and neurological conditions, with a focus on clinical, mechanistic, and potentially therapeutic implications.