Inflamm Bowel Dis. 2024 May 23;30(Supplement_2):S55-S66.doi: 10.1093/ibd/izae083.

Jessica R Allegretti ¹, Liliana G Bordeianou ², Oriana M Damas ³, Samuel Eisenstein ⁴, Ruby Greywoode ⁵, Phillip Minar ^6 7, Siddharth Singh ^8 9, Sabrina Harmon ⁶, Eugene Lisansky ¹⁰, Myisha Malone-King ⁶, Nicole S Litwin ¹¹, Alandra Weaver ¹¹, Caren A Heller ¹¹, Alan C Moss ¹¹, Jeremy Adler ¹²

Author information

¹Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA.

²Department of General and Gastrointestinal Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

³Division of Gastroenterology, Department of Medicine, University of Miami Leonard Miller School of Medicine, Miami, FL, USA.

⁴Division of Colon and Rectal Surgery, Department of Surgery, University of California San Diego, La Jolla, CA, USA.

⁵Division of Gastroenterology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.

⁶Division of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH, USA.

⁷Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

⁸Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA, USA.

⁹Division of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, CA, USA.

¹⁰Patient representative for Crohn's & Colitis Foundation, New York, NY, USA.

¹¹Crohn's & Colitis Foundation, New York, NY, USA.

¹²Susan B. Meister Child Health Evaluation and Research Center and Division of Pediatric Gastroenterology, C.S. Mott Children's Hospital, Michigan Medicine, Ann Arbor, MI, USA.

Abstract

Pragmatic clinical research is 1 of the 5 focus areas of the Challenges in IBD Research 2024, a multidisciplinary effort by scientists, clinicians, patients, and funders to identify priorities for patient-centric research. This summary provides a comprehensive overview of current gaps in inflammatory bowel disease (IBD) clinical research and actionable approaches to address them. This review is focused on identifying research that is needed to achieve the best outcomes for patients in clinical practice. Research gaps include understanding the needs of understudied patient groups and addressing barriers to care so all patients receive optimal care, validating and using biomarkers to enable early diagnosis and result in better outcomes for adults and children with IBD, and determining the optimal sequencing of treatments (medical, surgical, adjunct) in children and adults. Inclusive pragmatic research is needed to address these gaps and lead to improvements in patient care and outcomes for all populations of patients with IBD.