J Pediatr Gastroenterol Nutr. 2024 May;78(5):1149-1154. doi: 10.1002/jpn3.12191.Epub 2024 Mar 21

Nicole Du ^1 2, Clarivet Torres ¹

Author information

¹Pediatric Residency Program, Children's National Hospital, Washington, District of Columbia, USA.

²Division of Pediatric Gastroenterology, Children's National Hospital, Washington, District of Columbbia, USA.

Abstract

Patients with short bowel syndrome (SBS) have multiple risk factors for eosinophilic gastrointestinal diseases (EGIDs) including increased risk for intestinal dysbiosis and food allergy compared to their counterparts with normal anatomy. However, there is limited data on the prevalence of EGIDs in children with SBS. We aimed to define the prevalence of EGIDs in an SBS cohort and its association with different risk factors via a retrospective chart review of patients with SBS at Children's National Hospital. The prevalence of eosinophilic esophagitis in our SBS cohort was 10%, eosinophilic gastritis was 4.9%, and eosinophilic enteritis was 4.9%. SBS patients with history of allergy or atopy were more likely to have esophageal and intestinal eosinophilia on biopsy than patients without allergy. The prevalence of EGIDs in our SBS cohort is significantly higher than in the general population and may be associated with allergic polarization.