Clin Pediatr (Phila). 2024 Feb 19:99228241232876. doi: 10.1177/00099228241232876.Online ahead of print.

Arielle Bergman ^1 2, Melanie Greifer ¹, Jeremiah Levine ¹

Author information

¹Weill Cornell Medicine, Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, New York, NY, USA.

²Division of Pediatric Gastroenterology & Hepatology, Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA.

Abstract

Celiac disease (CeD) and eosinophilic esophagitis (EoE) are immune-mediated disorders that can occur in the same patient. A retrospective study at a tertiary care hospital was conducted to determine the prevalence of EoE in a pediatric population with CeD and to compare characteristics of patients with both diseases to patients with CeD-only. Among the 148 patients with CeD identified in the study, 11 patients had both CeD and EoE (7.4%). Patients with both CeD and EoE had a higher absolute eosinophil count (per μL) at diagnosis compared to patients with CeD-only (454.1 ± 122.7 vs 231.9 ± 19.4, P = .003). In conclusion, there was a higher proportion of EoE in patients with CeD than would be expected in the general population, suggesting a potential pathophysiological overlap between the 2 diseases. An elevated peripheral absolute eosinophil count may help predict which patients with CeD may additionally have EoE.