J Crohns Colitis. 2022 Jul 1;jjac095. doi: 10.1093/ecco-jcc/jjac095. Online ahead of print.

Laura Arp ^1 2, Sabine Jansson ^2 3, Vibeke Wewer ^2 3, Johan Burisch ^1 2

Author information

¹Gastrounit, Medical Section, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.

²Copenhagen Centre for Inflammatory Bowel Disease in Children, Adolescent and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.

³The Paediatric Department, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.

Abstract

Background: Inflammatory bowel diseases (IBD), which are associated with a high disease burden, are also reported to be accompanied by a high prevalence of psychiatric disorders. However, the literature on IBD and psychiatric disorders has not been reviewed.

Methods: This systematic review followed the PRISMA guidelines, and its protocol was registered at PROSPERO (ID: CRD42020214359). PubMed, Embase and PsycINFO were consulted for the literature search. Studies reporting on diagnosed psychiatric disorders in IBD were included. Pooled prevalence rates were calculated using random effects meta-analyses. Study quality was assessed using the Newcastle-Ottawa Scale (NOS).

Results: Sixty-nine studies were identified with an average cohort size of 60,114 patients. Pooled prevalence rates were: mood disorders, 10% (95% CI=7%; 15%); anxiety disorders, 12% (95% CI=8%; 18%); substance misuse, 3% (95% CI=1%; 7%); psychotic disorders, 2% (95% CI=1%; 4%); behavioral disorders, 1% (95% CI=0%; 3%); personality disorders, 3% (95% CI=1%; 10%); developmental disorders, 1% (95% CI=0%; 3%); behavioral and emotional disorders with onset usually during childhood, 1% (95% CI=1%; 3%). All analyses had high statistical heterogeneity (I2 > 99%). Seven studies reported an increased risk of suicide in IBD patients compared to controls.

Conclusion: The prevalence of psychiatric comorbidities was high (11- 82%) in patients with IBD and was higher than in the background population. Addressing mental health problems in patients with IBD can improve their adherence to treatment and the somatic disease course and, consequently, reduce morbidity and mortality.