Inflamm Bowel Dis. 2022 Jan 18;izab319. doi: 10.1093/ibd/izab319. Online ahead of print.

Joseph Runde ^1 2, Amarachi Erondu ^3 2, Shintaro Akiyama ², Cindy Traboulsi ², Victoria Rai ², Laura R Glick ², Yangtian Yi ^3 2, Jacob E Ollech ², Russell D Cohen ², Kinga B Skowron ², Roger D Hurst ², Konstatin Umanskiy ², Benjamin D Shogan ², Neil H Hyman ², Michele A Rubin ², Sushila R Dalal ², Atsushi Sakuraba ², Joel Pekow ², Eugene B Chang ², David T Rubin ²

Author information

¹Section of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Comer Children's Hospital, Chicago, IL, USA.

²University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, IL, USA.

³Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.

Abstract

Background: Despite significant differences in surgical outcomes between pediatric and adult patients with ulcerative colitis (UC) undergoing colectomy, counseling on pediatric outcomes has largely been guided by data from adults. We compared differences in pouch survival between pediatric and adult patients who underwent total proctocolectomy with ileal pouch-anal anastomosis (IPAA).

Methods: This was a retrospective single-center study of patients with UC treated with IPAA who subsequently underwent pouchoscopy between 1980 and 2019. Data were collected via electronic medical records. We stratified the study population based on age at IPAA. Differences between groups were assessed using t tests and chi-square tests. Kaplan-Meier curves were used to compare survival probabilities. Differences between groups were assessed using a log-rank test.

Results: We identified 53 patients with UC who underwent IPAA before 19 years of age and 329 patients with UC who underwent IPAA at or after 19 years of age. Subjects who underwent IPAA as children were more likely to require anti-tumor nerosis factor (TNF) postcolectomy compared with adults (41.5% vs 25.8%; P < .05). Kaplan-Meier estimates revealed that pediatric patients who underwent IPAA in the last 10 years had a 5-year pouch survival probability that was 28% lower than that of those who underwent surgery in the 1990s or 2000s (72% vs 100%; P < .001). Further, children who underwent IPAA and received anti-TNF therapies precolectomy had the most rapid progression to pouch failure when compared with anti-TNF-naive children and with adults who were either exposed or naive precolectomy (P < .05).

Conclusions: There are lower rates of pouch survival for children with UC who underwent IPAA following the uptake of anti-TNF therapy compared with both historical pediatric control subjects and contemporary adults.