Dig Dis Sci. 2021 Jul;66(7):2240-2249. doi: 10.1007/s10620-020-06530-w. Epub 2020 Aug 14.

Melissa Martin ¹, Biyao Zou ², Joseph Hoang ², Donghak Jeong ², Rachel Bensen ¹, Mindie H Nguyen ³

Author information

¹Division of Pediatric Gastroenterology, Hepatology and Nutrition, Stanford University School of Medicine, 780 Welch Road, RM CJ250K, Palo Alto, CA, 94304, USA.

²Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 780 Welch Road, RM CJ250K, Palo Alto, CA, 94304, USA.

³Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 780 Welch Road, RM CJ250K, Palo Alto, CA, 94304, USA. mindiehn@stanford.edu.

Abstract

Background: Adult liver-related hospitalizations have recently increased in the USA, but data are limited for the pediatric population.

Aims: Utilizing the Office of Statewide Health Planning and Development hospital claims database (covering > 98% of all California hospitalizations), we aimed to characterize the demographic, clinical, and socioeconomic factors of liver disease-associated admissions among children between 2005 and 2015.

Methods: We used ICD-9 codes to identify admissions associated with liver disease in patients up to 21 years of age. Patient characteristics were described as percentages and evaluated using the χ² test. We used linear regression to examine changes over time.

Results: We analyzed 37,372 eligible admissions. Overall, close to one-third (28%) and one-half (48.0%) of admissions occurred in the age group 0-5 years and 16-21 years, respectively, with the remaining 23.1% occurring in the age group between 5 and 15 years. Over half (54.9%) were in males. By race, blacks made up half of the admission (49.7%), while by ethnicity, Hispanic also accounted for half of the admission (49.7%). Medicaid and Medicare payors were also disproportionately represented (54.6%). The most common liver disease was Alagille syndrome (29.2%) in 2005. Between 2005 and 2015, both the number of pediatric liver-associated admissions and the proportion of pediatric liver admissions over total admissions increased from 3130 to 3429 and 1.2% to 1.6%, respectively (both p = 0.001). By 2015, while Alagille syndrome admissions decreased to 26.4% (p = 0.004), NAFLD admission increased to 19.7% (p < 0.001).

Conclusion: Major disparities exist in inpatient liver disease burden for blacks and Hispanics with liver disease, while NAFLD emerged as a rapidly rising liver disease in pediatrics.