J Pediatr Gastroenterol Nutr. 2021 Jun 1. doi: 10.1097/MPG.0000000000003195.Online ahead of print.

Clémence Mercier ¹, Delphine Ley, Madeleine Aumar, Julie Lemale, Alexandre Fabre, Stéphanie Colinet, Alain Duhamel, Frédéric Gottrand

Author information

• ¹University Lille, Inserm, U1286 - Infinite, CHU Lille, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, F-59000 Lille, France Department of Pediatric Nutrition and Gastroenterology, Trousseau Hospital-APHP, Sorbonne University, Paris APHM, Timone Enfant, Service de pédiatrie multidisciplinaire, AP-HM, Marseille, France Aix Marseille Univ, INSERM, MMG, Marseille, France Gastroentérologie pédiatrique, Montlégia Hospital, CHC, Liège, Belgique Unité de Méthodologie, Biostatistique et Data Management, CHU de Lille, France.

Abstract

Objectives: The objective of this study was to assess the tolerance and efficacy of endoscopic intrapyloric botulinum toxin injection compared with pyloric dilatation in children with gastroparesis.

Methods: This was a retrospective descriptive multicentre study that included pediatric patients treated between 2010 and 2018 at four tertiary hospitals.

Results: Data were collected for 24 patients. The median age at diagnosis was 2.5 years (range 0.5-4.7). A total of 46 endoscopic procedures were performed. The endoscopic procedure was multiple in 63% of patients. Among the interventions, 76% were successful and 15% were unsuccessful. The recurrence rate was 57% and the median time to recurrence was 3.7 months (0.1-73). The efficacy did not differ significantly between the two methods at the first intervention and as a second-line treatment. The recurrence rate also did not differ significantly between the two methods. No complications were reported. The median follow-up was 19.8 months (1.7-61.7).

Conclusions: In this retrospective multicentre study, endoscopic management of gastroparesis by balloon dilatation or botulinum toxin was safe in children and seemed to be partially efficient within the first months. Symptoms recurred frequently and required repetition of the interventions.