J Pediatr Gastroenterol Nutr. 2021 Mar 1;72(3):384-387. doi: 10.1097/MPG.0000000000002953.

Benjamin Sahn ¹, Ogechukwu P Eze ², Morris C Edelman ³, Christina E Chougar ⁴, Rebecca M Thomas ², Charles L Schleien ⁵, Toba Weinstein ⁶

Author information

• ¹Division of Gastroenterology, Liver Disease, and Nutrition, Department of Pediatrics.
• ²Department of Pathology and Laboratory Medicine.
• ³Division of Pediatric Pathology, Zucker School of Medicine at Hofstra/Northwell, Steven & Alexandra Cohen Children's Medical Center, Northwell Health.
• ⁴Department of Radiology, Long Island Jewish Medical Center/Northwell Health.
• ⁵Philip Lanzkowsky Chair of Pediatrics.
• ⁶Division of Gastroenterology, Liver Disease, and Nutrition, Department of Pediatrics, Zucker School of Medicine at Hofstra/Northwell, Steven & Alexandra Cohen Children's Medical Center, Northwell Health.

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a recently identified syndrome that appears to be temporally associated with novel coronavirus 2019 infection. MIS-C presents with fever and evidence of systemic inflammation, which can manifest as cardiovascular, pulmonary, neurologic, and gastrointestinal (GI) system dysfunction. Presenting GI symptoms are seen in the majority, including abdominal pain, diarrhea, and vomiting. Any segment of the GI tract may be affected; however, inflammation in the ileum and colon predominates. Progressive bowel wall thickening can lead to luminal narrowing and obstruction. Most will have resolution of intestinal inflammation with medical therapies; however, in rare instances, surgical resection may be required.