J Pediatr. 2020 Sep;224:158-161.e2. doi: 10.1016/j.jpeds.2020.04.009.Epub 2020 Jun 24.

Muhammad Rehan Khan ¹, Jocelyn A Silvester ², Brandon Sparks ³, Zackary Hintze ², Tracy Ediger ³, Joseph J Larson ⁴, Ivor Hill ³, Imad Absah ⁵

Author information

• ¹Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Division of Pediatric Gastroenterology & Hepatology, Rochester, MN. Electronic address: khan.muhammad1@mayo.edu.
• ²Department of Pediatrics, Harvard Celiac Research Program, Boston Children's Hospital, Boston, MA.
• ³Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH.
• ⁴Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
• ⁵Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Division of Pediatric Gastroenterology & Hepatology, Rochester, MN.

Abstract

Current screening guidelines in North America for celiac disease recommend additional IgG based testing for younger children. Our multicenter retrospective study showed that the anti-tissue transglutaminase IgA antibody test should be the recommended initial test in all children, including those ≤24 months of age.