Kim, Beom-Jun (BJ);Jo, Yunju (Y);Baek, Ji Yeon (JY);Park, So Jeong (SJ);Jung, Hee-Won (HW);Lee, Eunju (E);Jang, Il-Young (IY);Sakong, Hyuk (H);Ryu, Dongryeol (D);

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J Nutr Health Aging.2025 Feb 20;29(5):100521.doi:10.1016/j.jnha.2025.100521

Abstract

BACKGROUND: Despite the pleiotropic role of resistin as an adipokine, its association with frailty-an indicator of biologic age and overall well-being in humans-remains largely unexplored. This study aims to investigate the potential of circulating resistin as a biomarker for frailty.

METHODS: The study included 228 older adults aged 65 years or older who underwent a comprehensive geriatric assessment. Frailty was evaluated using both the phenotypic frailty model by Fried and the deficit-accumulation frailty index (FI) by Rockwood. Serum resistin levels were measured using a competitive enzyme-linked immunosorbent assay.

RESULTS: After adjusting for sex, age, body mass index, smoking, alcohol, exercise, diabetes, and serum creatinine, serum resistin levels were 52.2% higher in individuals with phenotypic frailty than in robust controls (P =  0.001) and showed a positive correlation with the Rockwood FI (P =  0.015). Furthermore, for every 1 standard deviation increase in serum resistin levels, the risk of frailty increased by 67% (P =  0.021). When participants were divided into four groups based on serum resistin levels, individuals in the highest quartile had a 38% higher FI and exhibited a 12.5-fold higher odds ratio for frailty compared to those in the lowest quartile (P =  0.016 and 0.024, respectively).

CONCLUSION: These findings suggest that circulating resistin may serve as a candidate blood-based biomarker for frailty, encompassing the multifaceted physical, cognitive, and social dimensions, extending beyond its well-established role in metabolic regulation.