Aliment Pharmacol Ther. 2023 Mar 13. doi: 10.1111/apt.17465. Online ahead of print.

Vivek C Goodoory ^1 2, Cho E Ng ³, Christopher J Black ^1 2, Alexander C Ford ^1 2

Author information

¹Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.

²Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.

³County Durham and Darlington NHS Foundation Trust, Durham, UK.

Abstract

Background: Little is known about faecal incontinence (FI) in individuals with irritable bowel syndrome (IBS).

Aims: To compare characteristics of people with IBS reporting FI, compared with people with IBS who do not report FI.

Methods: We collected demographic, gastrointestinal and psychological symptoms, healthcare usage, direct healthcare costs, impact on work and activities of daily living, and quality of life data from individuals with Rome IV-defined IBS. We asked participants about FI, assigning presence or absence according to Rome-IV criteria.

Results: Of 752 participants with Rome IV IBS, 202 (26.9%) met Rome IV criteria for FI. Individuals with FI were older (p < 0.001), more likely to have IBS-D (47.0% vs. 39.0%, p = 0.008), and less likely to have attained a university or postgraduate level of education (31.2% vs. 45.6%, p < 0.001), or to have an annual income of ≥£30,000 (18.2% vs. 32.9%, p < 0.001). They were more likely to report urgency (44.6% vs. 19.1%, p < 0.001) as their most troublesome symptom and a greater proportion had severe IBS symptom scores, abnormal depression scores, higher somatic symptom-reporting scores or higher gastrointestinal symptom-specific anxiety scores (p < 0.01 for trend for all analyses). Mean health-related quality of life scores were significantly lower among those with, compared with those without, FI (p < 0.001). Finally, FI was associated with higher IBS-related direct healthcare costs (p = 0.002).

Conclusions: Among individuals with Rome IV IBS, one-in-four repo rted FI according to Rome IV criteria. Physicians should ask patients with IBS about FI routinely.