Clinical Assistant Professor, Gastroenterology
Director, Gastrointestinal Motility and Neurogastroenterology
Stanford University Medical Center

Dr. Nguyen is a Clinical Assistant Professor of Medicine in the Division of Gastroenterology at Stanford University. She is the Director of Gastrointestinal Motility and Neurogastroenterology. Dr. Nguyen’s clinic focuses on GI motility and functional GI disorders. She provides comprehensive motility testing when appropriate, to help diagnose and treat these conditions.

Dr. Nguyen’s research focus is on gastroparesis, evaluating the impact of various physiologic tests and therapies on patient outcomes and quality of life. She continues to study gastroparesis in her role as an investigator in the NIH sponsored Gastroparesis Clinical Research Consortium. She has recently taken an interest in evaluating the impact of pain through a multidisciplinary approach as it pertains to patient outcomes and quality of life.

Stanford School of Medicine
Department of Gastroenterology & Hepatology

The Division of Gastroenterology and Hepatology has a long tradition of major contributions in basic research, a new commitment to clinical and outcomes research, a track record of training fellows for academic careers, and a longitudinal commitment to providing care for patients with complex gastrointestinal and liver diseases. The GI Motility and Neurogastroenterology section provides comprehensive motility testing spanning the esophagus to the anorectum and includes breath testing for small intestinal bacterial overgrowth and carbohydrate malabsorption.

 Kuvan® (Sapropterin Dihydrochloride) for Improving Gastric Accommodation in Women With Diabetic Gastroparesis (KIGA-DG)

The Purpose of This Pilot Study is to Assess the Impact of KUVAN® (Sapropterin Dihydrochloride) on Gastric Relaxation in Women With Diabetic Gastroparesis.

Primary Outcome Measures:
• Gastric accommodation [ Time Frame: Change in total volume consumed during the satiety test from baseline to end of treatment. ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
1) secondary outcome measures will include improvement in symptom severity. [ Time Frame: Improvement in symtoms after 4 weeks of Kuvan 10mg/kg and 4 weeks of Kuvan 20 mg/kg. ] [ Designated as safety issue: No ]

2) secondary outcome measures will include improvement in quality of life. [ Time Frame: Improvement in quality of life after 4 weeks of Kuvan 10mg/kg and 4 weeks of Kuvan 20 mg/kg ] [ Designated as safety issue: No ]

3) secondary outcome measures will include improvement in gastric emptying. [ Time Frame: Improvement in gastric emptying after 4 weeks of Kuvan 10mg/kg and 4 weeks of Kuvan 20 mg/kg ] [ Designated as safety issue: No ]

Estimated Enrollment: 20
Study Start Date: May 2010
Estimated Study Completion Date: March 2011
Estimated Primary Completion Date: November 2010 (Final data collection date for primary outcome measure)

Ages Eligible for Study: 18 Years to 65 Years
Genders Eligible for Study: Female
Accepts Healthy Volunteers: No

 Gastroparesis Registry 2 (GpR2)

To expand a registry of patients for the study of the epidemiology, etiology, and degree of morbidity associated with gastroparesis.

Estimated Enrollment: 500
Study Start Date: July 2012
Estimated Study Completion Date: September 2017
Estimated Primary Completion Date: August 2017 (Final data collection date for primary outcome measure)

 Clinical Management With SPM System and Validation of the SPM 5 Hour Cutoff in Patients With Symptoms of Gastroparesis

This protocol is designed to validate use of the SPM for diagnosis of delayed gastric emptying in patients with symptoms of gastroparesis and assess impact of a SmartPill study on patient management in the gastroparetic populations. Patients with symptoms of gastroparesis will be recruited.

Patients will undergo concurrent gastric scintigraphy and SPM testing to determine the presence or absence of delayed gastric emptying based on predetermined diagnostic cutoffs for each technique.

Estimated Enrollment: 250
Study Start Date: January 2014
Estimated Study Completion Date: July 2016
Estimated Primary Completion Date: January 2016 (Final data collection date for primary outcome measure)